Reprogramming T Cell Fate and Antitumor Function by MicroRNA Therapeutics
Time: 5:00 pm
day: Day 1 – Track A – Evening
• Overexpression of miR-155 enhances homeostatic cytokine signaling overcoming the need of lymphodepletion preconditioning.
• miR-155 modulates T cell epigenetic circuitry to restrict terminal differentiation and functional exhaustion.
• A human miR-155 SNP boost CAR T cell polyfunctionality and antitumor responses more effectively than its wild-type counterpart